Drugs for stroke: Action of nitrone (Z)-N-(2-bromo-5-hydroxy-4- methoxybenzylidene)-2-methylpropan-2-amine oxide on rat cortical neurons in culture subjected to oxygen-glucose-deprivation

Carmen Arce, Sabela Diaz-Castroverde, María J. Canales, José Marco-Contelles, Abdelouahid Samadi, María J. Oset-Gasque, María P. González

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11 Citations (Scopus)

Abstract

The action of (Z)-N-(2-bromo-5-hydroxy-4-methoxybenzylidene)-2- methylpropan-2-amine oxide (RP6) on rat cortical neurons in culture, under oxygen-glucose-deprivation conditions, is reported. Cortical neurons in culture were treated during 1 h with OGD. After, they were placed under normal conditions during 24 h (reperfusion) in absence and presence of RP6. Different parameters were measured under each condition (control, 1 h OGD and 1 h OGD + reperfusion in absence and presence of RP6). RP6 protects neurons against ROS generation, lipid peroxidation levels, LDH release and mitochondrial membrane potential alteration, when administered during reperfusion after the OGD damage. Consequently, these results show that nitrone RP6 protects cells against ischemia injury produced during the reoxygenation, and could be a potential drug for the ictus therapy.

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume55
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

Keywords

  • Apoptosis
  • Cortical neurons
  • Ischemia
  • Lipid peroxidation
  • Necrosis
  • Neuroprotection
  • Nitrones
  • ROS

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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