Dose-response comparisons of canine plasma gastroenteropancreatic hormone responses to bombesin and the porcine gastrin-releasing peptide (GRP)

T. J. McDonald, M. A. Ghatei, S. R. Bloom, T. E. Adrian, T. Mochizuki, C. Yanaihara, N. Yanaihara

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)

Abstract

This study compares the potencies of the porcine gastrin-releasing peptide (pGRP) and bombesin, in causing elevations of canine plasma gastroenteropancreatic (GEP) levels. In the dose range 0-600 pmol · kg-1 · h-1, infusion of both peptides resulted in obvious dose-related elevations of plasma levels of gastrin, pancreatic polypeptide, enteroglucagon, immunoreactive pancreatic glucagon, and insulin. In this dose range, no significant difference in potency between the two peptides in elevating plasma levels of the above hormones was observed. The results of this study, demonstrating equimolar potency of pGRP and bombesin, are in contrast to previous studies reporting that pGRP was less potent than bombesin in causing certain bioactivities in the rat following intracranial administration of the two peptides.

Original languageEnglish
Pages (from-to)125-137
Number of pages13
JournalRegulatory Peptides
Volume5
Issue number2
DOIs
Publication statusPublished - Jan 1983
Externally publishedYes

Keywords

  • enteroglucagon
  • gastric inhibitory polypeptide
  • gastrin
  • insulin
  • pancreatic glucagon
  • pancreatic polypeptide

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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