Analysis of the spread of activity in the heart, the study of the mechanism of arrhythmias, and investigating the effects of anti-arrhythmic drugs are often performed by recording from a large number of electrodes simultaneously (> 100 extra cellular electrodes) and reconstructing the pattern of activation; i.e. electrical high-density mapping. An attempt was made to determine whether it was also possible to reconstruct the pattern of electrical activity in the gastrointestinal system using a similar mapping system. The first studies described in this report were performed in isolated rabbit duodenum and show that visualisation of the origin and spread of slow wave activity in the intestine is indeed possible. Furthermore, initial studies also revealed that quantification of conduction and conduction properties using the data acquired with the mapping system is feasible. In conclusion, high-density mapping of the electrical activity in the gastrointestinal wall may well follow in the footsteps of similar studies in the heart in determining the physiology and pathophysiology of electrical conduction in the gastrointestinal tract. High-density mapping may then also play a role in elucidating the mechanisms of existing drugs and be of benefit in the development of new drugs.
|Number of pages||5|
|Journal||International Pharmacy Journal|
|Publication status||Published - 1994|
ASJC Scopus subject areas
- Pharmaceutical Science