Decreased plasma insulin-like growth factor-I level in familial Alzheimer's disease patients carrying the Swedish APP 670/671 mutation

Amged Mustafa, Lars Lannfelt, Lena Lilius, Atiqul Islam, Bengt Winblad, Abdu Adem

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

The plasma insulin-like growth factor I (IGF-I) level was determined in family members carrying the Swedish amyloid precursor protein (APP) 670/671 mutation with or without Alzheimer's disease (AD) and in age-matched controls from the same family. Plasma growth hormone (GH) and prolactin (PRL) levels were also determined. Measurement of the plasma IGF-I level by radioimmunoassay revealed a significant reduction only in the family members with AD compared to age-matched controls. However, there was no significant difference in the levels of GH and PRL between the mutation carriers with or without AD and their respective age-matched controls. These findings indicate that the mechanism(s) regulating GH and PRL were preserved and those regulating IGF-I levels might be affected in AD patients with the Swedish APP 670/671 mutation.

Original languageEnglish
Pages (from-to)446-451
Number of pages6
JournalDementia and Geriatric Cognitive Disorders
Volume10
Issue number6
DOIs
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • APP 670/671 mutation
  • Alzheimer's disease
  • Growth hormone
  • Insulin-like growth factor I
  • Prolactin

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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