Cucurbituril Ameliorates Liver Damage Induced by Microcystis aeruginosa in a Mouse Model

Na'il Saleh, Saad Al-Jassabi, Ali H. Eid, Werner M. Nau

Research output: Contribution to journalArticlepeer-review

Abstract

Microcystis aeruginosa is a cyanobacterium that produces a variety of cyclic heptapeptide toxins in freshwater. The protective effects of the macromolecular container cucurbit[7]uril (CB7) were evaluated using mouse models of cyanotoxin-induced liver damage. Biochemical analysis of liver function was performed to gauge the extent of liver damage after exposure to cyanobacterial crude extract [CCE; LD50 = 35 mg/kg body weight; intraperitoneal (i.p.)] in the absence or presence of CB7 (35 mg/kg body weight, i.p.). CCE injection resulted in liver enlargement, potentiated the activities of alanine aminotransferase (ALT) and glutathione S-transferase (GST), increased lipid peroxidation (LPO), and reduced protein phosphatase 1 (PP1) activity. CCE-induced liver enlargement, ALT and GST activities, and LPO were significantly reduced when CB7 was coadministered. Moreover, the CCE-induced decline of PP1 activity was also ameliorated in the presence of CB7. Treatment with CB7 alone did not affect liver function, which exhibited a dose tolerance of 100 mg/kg body wt. Overall, our results illustrated that the addition of CB7 significantly reduced CCE-induced hepatotoxicity (P < 0.05).

Original languageEnglish
Article number660927
JournalFrontiers in Chemistry
Volume9
DOIs
Publication statusPublished - Apr 14 2021

Keywords

  • Microcystis aeruginosa
  • chemoprotectant
  • cucurbituril
  • cyanobacterial crude extract
  • liver damage

ASJC Scopus subject areas

  • Chemistry(all)

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