Crocus sativus L. Extract containing polyphenols modulates oxidative stress and inflammatory response against anti-tuberculosis drugs-induced liver injury

Adil Farooq Wali, Jayachithra Ramakrishna Pillai, Yusra Al Dhaheri, Muneeb U. Rehman, Ambreen Shoaib, Omar Sarheed, Salma Jabnoun, Maryam Razmpoor, Saiema Rasool, Bilal Ahmad Paray, Parvaiz Ahmad

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The purpose of this study is to analyze the polyphenolic rich extract of Crocus sativus L. petals (CSP) in modulating liver oxidative stress and inflammatory response status against rifampicin isoniazid (INH-RIF) drug-induced liver injury. The INH-RIF was administered for 14 days with varying doses in Wistar rats, while silymarin was administered as standard dose. We report the defensive impacts of CSP against INH-RIF induced liver oxidative stress and proinflammatory cytokine. The CSP treatment at both doses significantly controlled all modulating biochemical hepatic injury indicators and resulted in the attenuation of arbitral INH-RIF damage. The components present in CSP identified by LC–ESI-Q-TOF–MS were found to be flavonoids and fatty acids. It can be inferred that CSP possesses a hepatoprotective capacity against INH-RIF-mediated hepatic injury, which may prove to be a medically beneficial natural product for the management of drug-induced liver injury.

Original languageEnglish
Article number167
JournalPlants
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 2020

Keywords

  • Anti-tuberculosis
  • Crocus sativus
  • Cytokines
  • Hepato-toxicity
  • Polyphenols
  • Silymarin

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Plant Science

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