Consumption of sesame oil muffins decreases the urinary excretion of γ-tocopherol metabolites in humans

Jan Frank, Afaf Kamal-Eldin, Maret G. Traber

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Sesame seed and oil consumption previously increased human plasma γ-tocopherol (γ-T) concentrations. This was attributed to the sesame lignans sesamin and sesamolin. Here, we studied the inhibition of vitamin E metabolism by a single dose of sesame oil lignans coingested with deuterated α- and γ-tocopherols in human volunteers. The urinary excretion of γ-T metabolites was significantly lower in sesame oil treated than in control subjects. Concentrations of tocopherols in blood were not affected by the treatment. In conclusion, a single dose of sesame oil, containing 136 mg sesame lignans (sesamin and sesamolin), reduces the urinary excretion of co-administered γ-T in humans.

Original languageEnglish
Pages (from-to)365-367
Number of pages3
JournalAnnals of the New York Academy of Sciences
Volume1031
DOIs
Publication statusPublished - Jan 1 2004
Externally publishedYes

Keywords

  • CEHC
  • Carboxyethyl hydroxychromans
  • Lignans
  • Sesame
  • Sesamin
  • Sesamolin
  • Tocopherol
  • Vitamin E

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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