Combined serum free light chain levels are associated with carotid atherosclerosis in type 2 diabetes mellitus

Felix Aberer, Norbert Joachim Tripolt, Hubert Scharnagl, Julian Zedler, Michaela Eder, Abderrahim Oulhaj, Tatjana Stojakovic, Harald Sourij

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Patients with type 2 diabetes mellitus face an increased risk of cardiovascular events compared to non-diabetic counterparts. Chronic inflammation and activation of the immune system, including B-lymphocyte maturation is believed to play a role in atherosclerosis. Recent investigations suggest combined serum free light chains as a potential biomarker for cardiovascular events. The aim of this analysis was to investigate the association of combined serum free light chain with carotid atherosclerosis in subjects with type 2 diabetes mellitus. Methods: We performed a cross-sectional analysis of data from a prospective single centre 2-year study of 97 patients with type 2 diabetes mellitus and insufficiently controlled cardiovascular risk factors. Complete data on combined serum free light chain, high-sensitivity C-reactive protein were available for 75 subjects. Results: We analysed data of 26 female and 49 male subjects, aged 59 ± 8 years. Their mean body mass index was 31.6 ± 4.4 kg/m2, and the median B-score was 2 (interquartile range: 0–3). Significant positive correlations between combined serum free light chain and the B-score (r = 0.38; p = 0.001) as well as combined serum free light chain and high-sensitivity C-reactive protein (r = 0.35; p = 0.002) were observed. The adjusted odds ratio for a half standard deviation increase in combined serum free light chain was 1.48 (95% confidence interval: 1.05–2.05) in an ordinal regression model for carotid B-score. Conclusion: In our study, combined serum free light chain was associated with carotid atherosclerosis in subjects with type 2 diabetes mellitus.

Original languageEnglish
Pages (from-to)162-164
Number of pages3
JournalDiabetes and Vascular Disease Research
Volume15
Issue number2
DOIs
Publication statusPublished - Mar 1 2018

Keywords

  • Free light chains
  • atherosclerosis
  • clinical trial
  • diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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