Cognitive discernible factors between schizophrenia and schizoaffective disorder

Emmanuel Stip, Amir Ali Sepehry, Antoinette Prouteau, Catherine Briand, Luc Nicole, Pierre Lalonde, Alain Lesage

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

Background: Schizophrenia (SZ) and schizoaffective disorders (SA) are associated with cognitive deficits. Generally, a schizoaffective diagnosis is associated with better prognosis on the level of social integration. It is also well established that cognition is an important factor for good social outcome in schizophrenia. We hypothesized that, although patients suffering from SA share symptoms with SZ, they can be differentiated on the basis of neurocognitive function and that SA perform better in several domains. Method: Performances of two groups SA (N = 13) and SZ (N = 44) were compared on several visual-motor tasks using CANTAB [Motor Screening (MOT), Reaction Time (RTI), Paired Associates Learning Task (PAL), and Stockings of Cambridge items (SOC)]. The two groups were matched for symptom severity. ANOVA with repeated measures was employed to determine whether any difference in cognitive scores during a 2-year period was significantly related to the diagnostic status. Results: A significant and durable difference was observed between SZ and SA on motor screening and explicit memory tests where SA performed better. Conclusion: Neurocognitive tests may be relevant for distinguishing schizoaffective from schizophrenia, chiefly via tests tapping into visuo-spatial and visuo-motor coordination abilities (e.g., paired associated learning and motor screening).

Original languageEnglish
Pages (from-to)292-295
Number of pages4
JournalBrain and Cognition
Volume59
Issue number3
DOIs
Publication statusPublished - Dec 2005
Externally publishedYes

Keywords

  • CANTAB
  • Neurocognition
  • Paired associated learning
  • Schizoaffective disorder
  • Schizophrenia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

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