Childhood diarrhoea in the eastern mediterranean region with special emphasis on non-typhoidal salmonella at the human–food interface

Ali Harb, Mark O’Dea, Sam Abraham, Ihab Habib

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Diarrhoeal disease is still one of the most challenging issues for health in many countries across the Eastern Mediterranean region (EMR), with infectious diarrhoea being an important cause of morbidity and mortality, especially in children under five years of age. However, the understanding of the aetiological spectrum and the burden of enteric pathogens involved in diarrhoeal disease in the EMR is incomplete. Non-typhoidal Salmonella (NTS), the focus of this review, is one of the most frequently reported bacterial aetiologies in diarrhoeal disease in the EMR. Strains of NTS with resistance to antimicrobial drugs are increasingly reported in both developed and developing countries. In the EMR, it is now widely accepted that many such resistant strains are zoonotic in origin and acquire their resistance in the food-animal host before onward transmission to humans through the food chain. Here, we review epidemiological and microbiological aspects of diarrhoeal diseases among children in the EMR, with emphasis on the implication and burden of NTS. We collate evidence from studies across the EMR on the zoonotic exposure and antimicrobial resistance in NTS at the interface between human and foods of animal origin. This review adds to our understanding of the global epidemiology of Salmonella with emphasis on the current situation in the EMR.

Original languageEnglish
Article number60
JournalPathogens
Volume8
Issue number2
DOIs
Publication statusPublished - Jun 2019
Externally publishedYes

Keywords

  • Child diarrhoea
  • Eastern Mediterranean region
  • Enteropathogens
  • Non-typhoidal Salmonella
  • Zoonoses

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Childhood diarrhoea in the eastern mediterranean region with special emphasis on non-typhoidal salmonella at the human–food interface'. Together they form a unique fingerprint.

Cite this