Chelating efficacy of CaNa2 EDTA on nickel-induced toxicity in Cirrhinus mrigala (Ham.) through its effects on glutathione peroxidase, reduced glutathione and lipid peroxidation

Rengaswamy Gopal, S. Narmada, Remya Vijayakumar, Cheruth Abdul Jaleel

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

In this age of modern biology, aquatic toxicological research has provided potential tools for ecotoxicologic investigations. Heavy metals primarily affect protein structures and induce a stress in the organisms. The present investigation was carried out to assess the effect of nickel chloride on the selected organs of the freshwater fish Cirrhinus mrigala and how CaNa2 EDTA counters its effects as an antidote. Toxicity experiments were conducted for different exposure periods and also in certain tissues namely gill, liver, kidney and muscle. The total protein content, reduced glutathione, glutathione peroxidase and lipid peroxidation were found to be decreased in the nickel chloride treated tissues and the treatment with CaNa2 EDTA + nickel chloride returned to near normal levels. Histopathological observations also revealed that after the administration of nickel chloride + CaNa2 EDTA the chelator induced reduction in nickel toxicity. It has also contributed towards reduction in the pathological damage, thus enabling the organs to attain their near normal histological appearance. The present study shown that CaNa2 EDTA is an effective chelating agent for the removal of nickel and it has proved efficient in restoring both the biochemical variables and pathological features immediately after a sub lethal exposure of nickel chloride in fish. To cite this article: R. Gopal et al., C. R. Biologies 332 (2009).

Original languageEnglish
Pages (from-to)685-696
Number of pages12
JournalComptes Rendus - Biologies
Volume332
Issue number8
DOIs
Publication statusPublished - Aug 1 2009
Externally publishedYes

Keywords

  • CaNa EDTA
  • Cirrhinus mrigala
  • Glutathione peroxidase
  • Lipid peroxidation
  • Nickel chloride
  • Reduced glutathione

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

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