Changes in the somatostatin, substance P and vasoactive intestinal polypeptide content of the gastrointestinal tract following streptozotocin-induced diabetes in the rat

M. Ballmann, J. M. Conlon

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59 Citations (Scopus)

Abstract

Rats with streptozotocin-induced diabetes of 10 weeks' duration showed significant changes in the total content of somatostatin, substance P and vasoactive intestinal polypeptide in the stomach and small intestine compared with control animals. An increase (p<0.05) in the concentration and total content of gastric somatostatin and a decrease (p<0.05) in the concentration and content of gastric substance P were seen in the streptozotocin-treated rats. The increase in the vasoactive intestinal polypeptide (VIP) content (54%, p<0.05) and the decrease in the substance P content (35%, p<0.05) of the gut may contribute to the impaired intestinal motility observed in animals with experimentally produced diabetes. Both the diabetogenic effect of streptozotocin and the changes in regulatory peptide concentrations were prevented by injection of nicotinamide before streptozotocin suggesting that the changes did not arise from a non-specific toxic effect of streptozotocin upon gastrointestinal neurones and/or endocrine cells.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalDiabetologia
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 1985
Externally publishedYes

Keywords

  • Somatostatin
  • gastrointestinal tract
  • nicotinamide
  • rat
  • streptozotocin-diabetes
  • substance P
  • vasoactive intestinal polypeptide

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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