Changes in IGF-1 receptors in the hippocampus of adult rats after long- term adrenalectomy: Receptor autoradiography and in situ hybridization histochemistry

A. Islam, C. Ayer-Lelievre, C. Heigensköld, N. Bogdanovic, B. Winblad, A. Adem

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Alteration of insulin-like growth factor-1 (IGF-1) receptor and its mRNA after long-term adrenalectomy (ADX) was studied in the hippocampus by in vitro receptor autoradiography and in situ hybridization histochemistry, respectively. Significantly, decreased levels of IGF-1 receptor and its mRNA was noted in the dentate and CA1-CA4 regions of the hippocampus of the ADX animals, suggesting that the level and expression of IGF-1 receptors in the hippocampus is influenced by adrenal hormones.

Original languageEnglish
Pages (from-to)342-346
Number of pages5
JournalBrain Research
Volume797
Issue number2
DOIs
Publication statusPublished - Jun 29 1998
Externally publishedYes

Keywords

  • Apoptosis
  • Corticosteroid
  • Growth factor
  • Neurodegeneration

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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