Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains

Agneta Nordberg, Abdu Adem, John Hardy, Bengt Winblad

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)

Abstract

Competition experiments using (-)-[3H]nicotine and unlabelled nicotine revealed both high and low affinity nicotinic binding sites in temporal cortex of control and Alzheimer (AD/SDAT) brains. A significant reduction in the proportion of high affinity nicotinic binding sites (-20%) and a parallel increase in the proportion of low affinity nicotinic binding sites was obtained in AD/SDAT brain cortex compared to control brain. Moreover, a marked decrease was observed in the affinity of the low affinity nicotinic binding sites in AD/SDAT.

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalNeuroscience Letters
Volume86
Issue number3
DOIs
Publication statusPublished - Apr 12 1988
Externally publishedYes

Keywords

  • AD/SDAT
  • Alzheimer's disease
  • Dementia
  • Human brain
  • Nicotine, [H]-
  • Nicotinic receptor subtype
  • Temporal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

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