Change in meticillin-resistant Staphylococcus aureus clones at a tertiary care hospital in the United Arab Emirates over a 5-year period

Ágnes Sonnevend, Iain Blair, Mohammed Alkaabi, Pauline Jumaa, Mohammed Al Haj, Akela Ghazawi, Nadia Akawi, Fatima Saeed Jouhar, Mohammad Baraa Hamadeh, Tibor Pál

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Aims: Meticillin-resistant Staphylococcus aureus (MRSA) strains isolated in Tawam Hospital, a tertiary care hospital in the United Arab Emirates, were examined in order to understand the reasons for a doubling of its incidence between 2003 and 2008 while maintaining the same infection control measures. Methods: All consecutive non-duplicate clinically relevant MRSA isolates recovered between January and December 2003 and between May and October 2008 were studied. The antibiotic susceptibility, pulsed field gel electrophoresis, toxin gene, staphylococcal cassette chromosome mec (SCCmec), spa, agr and multilocus sequence types of the strains were tested. Results: In 2003, typical healthcare-associated (HA-MRSA) genotypes (ST239-MRSA-III, ST22-MRSA-IV and ST5-MRSA-II) represented the majority (61.5%) of the isolates. By 2008 this pattern had changed and clonal types considered as community-associated (CA) MRSA comprised 73.1% of the strains with ST80-MRSA-IV, ST5-MRSA-IV and ST1-MRSA with non-typable SCCmec types being the most frequent. However, further epidemiological investigations showed that only one-third of the CA-MRSA infections were actually acquired in the community, indicating that CA-MRSA clones have entered and spread within the hospital. Conclusions: The emergence of CA-MRSA clones with subsequent entry to and spread within the hospital has contributed to the increasing incidence of MRSA observed in Tawam Hospital and probably also in other hospitals in the UAE.

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalJournal of Clinical Pathology
Volume65
Issue number2
DOIs
Publication statusPublished - Feb 2012
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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