Central effects of trout tachykinins on heart rate variability in trout

Frédéric Lancien, Nagi Mimassi, John Michael Conlon, Jean Claude Le Mével

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Recent studies in trout have shown that tachykinins might be selectively implicated in important neuroregulatory functions related to the central control of ventilation. In teleost fish, cardiorespiratory coupling probably contributes to heart rate variability (HRV), and the hypoventilatory effects observed after central injection of tachykinins suggest that these peptides also may produce changes in HRV. Consequently, the present study was undertaken to compare the central actions of picomolar doses (25-250 pmol) of trout neuropeptide gamma (NPγ), substance P (SP), and neurokinin A (NKA) on HRV in unanesthetized rainbow trout. Compared to vehicle-injected trout, Poincaré plot analysis of HRV demonstrated that intracerebroventricular injection of NPγ dose dependently increased HRV. SP evoked a significant elevation of HRV but only at the highest dose (250 pmol). In contrast, NKA was without any effect on HRV. In conclusion, these results suggest that NPγ may be selectively implicated in the central control of HRV in trout.

Original languageEnglish
Title of host publicationTrends in Comparative Endocrinology and Neurobiology
PublisherBlackwell Publishing Inc.
Pages379-382
Number of pages4
ISBN (Print)9781573316712
DOIs
Publication statusPublished - Apr 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1163
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Heart rate variability
  • Neurokinin A
  • Neuropeptide γ
  • Poincaré plot analysis
  • Substance P
  • Teleosts

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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