Central and peripheral cardiovascular, ventilatory, and motor effects of trout urotensin-II in the trout

Jean Claude Le Mével, Frédéric Lancien, Nagi Mimassi, Jérôme Leprince, J. Michael Conlon, Hubert Vaudry

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

Urotensin-II (U-II) was originally considered to be exclusively the product of the caudal neurosecretory system (CNSS) of teleost fish, but it has now been demonstrated that U-II is widely expressed in peripheral tissues and nervous structures of species from lampreys to mammals. However, very little is known regarding the physiological effects of this peptide in its species of origin. In the present review, we summarize the most significant results relating to the cardiovascular, ventilatory, and motor effects of centrally and peripherally administered synthetic trout U-II in our experimental animal model, the unanesthetized trout Oncorhynchus mykiss. In addition, we compare the actions of U-II with those of other neurohormonal peptides, particularly with the actions of urotensin-I, a 41-amino acid residue peptide paralogous to corticotropin-releasing hormone that is co-localized with U-II within neurons of the CNSS.

Original languageEnglish
Pages (from-to)830-837
Number of pages8
JournalPeptides
Volume29
Issue number5
DOIs
Publication statusPublished - May 2008
Externally publishedYes

Keywords

  • Blood pressure
  • Brain
  • Heart rate
  • Intra-arterial injection
  • Intracerebroventricular injection
  • Locomotion
  • Neuropeptides
  • Ventilation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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