Cardiovascular actions of python bradykinin and substance P in the anesthetized python, Python regius

Tobias Wang, Michael Axelsson, Jorgen Jensen, J. Michael Conlon

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The cardiovascular actions of python bradykinin (BK) and substance P (SP) have been investigated in the anesthetized ball python, Python regius. Bolus intra-arterial injections of python BK (0.03-3 nmol/kg) produced concentration-dependent increases in arterial blood pressure, heart rate (HR), and cardiac output concomitant with small decreases in systemic resistance and stroke volume. Intra-arterial injection of 3 nmol/kg python BK produced a tenfold increase in circulating concentration of norepinephrine, but epinephrine levels did not change. BK-induced tachycardia was attenuated (>90%) by the β-adrenergic receptor antagonist sotalol, and the hypertensive response was attenuated (>70%) by the α-adrenergic receptor antagonist prazosin, indicating that effects of python BK are mediated at least in part by activation of the extensive network of adrenergic neurons present in vascular tissues. Bolus intra-arterial injections of python SP in the range 0.01-30 pmol/kg produced concentration-dependent decreases in arterial blood pressure and systemic peripheral resistance concomitant with increases in cardiac output and stroke volume but with only minor effects on HR. The data suggest that kinins play a physiologically important role in cardiovascular regulation in the python.

Original languageEnglish
Pages (from-to)R531-R538
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume279
Issue number2 48-2
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Adrenergic receptors
  • Kinin
  • Norepinephrine
  • Squamate
  • Vasoactive peptide

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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