Can misoprostol and omeprazole reduce nicotine and ethanol induced gastric mucosal injury? A quantitative macroscopic and microscopic analysis in rats

W. M. Hui, J. Ho, B. W. Chen, C. H. Cho, F. J. Branicki, S. K. Lam

Research output: Contribution to journalArticlepeer-review

Abstract

We compared the effects of misoprostol, omeprazole and methylcellulose (control) on gastric mucosal injury induced by nicotine and/or ethanol. The results demonstrate that misoprostol and omeprazole each significantly reduce macroscopic injury and deep injury at a microscopic level (P < 0.05) induced by nicotine alone, ethanol alone or a combination of ethanol and nicotine. Misoprostol and omeprazole each reduced the leakage of fluorescein isothiocyanate-albumin into the interstitium in the gastric mucosa. Misoprostol and omeprazole are each effective in preventing injury induced by nicotine and ethanol and vascular factors are involved.

Original languageEnglish
Pages (from-to)7-12
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 1 1997
Externally publishedYes

Keywords

  • Gastric
  • Macroscopic
  • Microscopic
  • Misoprostol
  • Omeprazole

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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