Bronchoalveolar matrix metalloproteinase 9 relates to restrictive lung function impairment in systemic sclerosis

Grethe Neumann Andersen, Kenneth Nilsson, Jamshid Pourazar, Tillie Louise Hackett, Elsadig Kazzam, Anders Blomberg, Anders Waldenström, Jane Warner, Solbritt Rantapää-Dahlqvist, Lucia Mincheva-Nilsson, Thomas Sandström

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Systemic sclerosis (SSc) is frequently associated with interstitial lung disease (ILD) often leading to lung fibrosis. In this study we investigated whether matrix metalloproteinase 9 (MMP-9) and its natural inhibitor; the tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), would be associated with remodelling in ILD in SSc. Levels of total MMP-9, pro-MMP-9 and TIMP-1 were measured in bronchoalveolar lavage (BAL) fluid from nine SSc patients with ILD, seven SSc patients without ILD and 16 age- and sex-matched healthy controls. Total MMP-9 and pro-MMP-9 levels were significantly elevated in SSc patients with ILD, compared to levels in SSc patients without ILD and healthy controls. In SSc patients with ILD calculated active MMP-9 levels were significantly higher than in SSc patients without ILD and tended to be higher than in healthy controls. TIMP-1 levels were elevated in both patient groups compared to healthy controls. Total-, pro- and active MMP-9 levels as well as pro-MMP-TIMP-1 and active MMP-9/TIMP-1 ratios were inversely associated with total lung capacity. The present study suggests that MMP-9 plays a pathophysiological role in the remodelling in ILD and lung fibrosis associated with SSc, and may represent a new therapeutic target in this condition.

Original languageEnglish
Pages (from-to)2199-2206
Number of pages8
JournalRespiratory Medicine
Volume101
Issue number10
DOIs
Publication statusPublished - Oct 2007

Keywords

  • Bronchoalveolar lavage
  • Interstitial lung disease
  • MMP9
  • Systemic sclerosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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