BREAST vs BOTTLE: ENDOCRINE RESPONSES ARE DIFFERENT WITH FORMULA FEEDING

A. Lucas, A. M. Blackburn, A. Aynsley-Green, D. L. Sarson, T. E. Adrian, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

195 Citations (Scopus)

Abstract

Differences in pancreatic and gut-hormone release between breast-fed and bottle-fed infants have not been documented although these hormones may play a key role in postnatal adaptation. In a study of 77 six-day-old healthy term infants, bottle-fed neonates ('Cow and Gate Premium') had significant changes in plasma-concentrations of insulin, motilin, enteroglucagon, neurotensin, and pancreatic polypeptide after feeding, whereas in breast-fed infants these changes were reduced or absent. Basal levels of gastric inhibitory polypeptide, motilin, neurotensin, and vasoactive intestinal peptide were also higher in the bottle-fed infants than in those who were breast-fed. These findings may partly explain differences in the deposition of subcutaneous fat and in stool frequency between breast-fed and bottle-fed neonates.

Original languageEnglish
Pages (from-to)1267-1269
Number of pages3
JournalThe Lancet
Volume315
Issue number8181
DOIs
Publication statusPublished - Jun 14 1980
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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