Behavioural deficits in adult rats following long-term adrenalectomy

Atiqul Ishm, Bengt Henriksson, Abdul Mohammed, Bengt Winblad, Abdu Adem

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Long-term adrenalectomy results in loss of neurones in the hippocampal formation of the adult rat. The effects of long-term adrenalectomy on spatial learning and exploratory behaviour in adrenalectomized (ADX), adrenalectomized normal weight gain (ADXNW), sham operated and naive control male Sprague-Dawley rats were investigated in this study. The ADX rats had significantly longer latencies in the Morris maze task compared to the other groups. In the open-field situation, as a novel finding, the ADX rats showed significantly lower rearing scores compared to other groups. These data indicate that long-term adrenalectomy causes impairment in spatial learning and explorative behaviour in the rat.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalNeuroscience Letters
Volume194
Issue number1-2
DOIs
Publication statusPublished - Jul 14 1995
Externally publishedYes

Keywords

  • Adrenalectomy
  • Exploratory behaviour
  • Hippocampus
  • Locomotion
  • Morns water maze
  • Rearing
  • Spatial learning

ASJC Scopus subject areas

  • Neuroscience(all)

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