Atomoxetine in Attention-Deficit/Hyperactivity Disorder in Children with and without Comorbid Mood Disorders

Nermin M. Shaker, Yara Osama, Doaa H. Barakat, Ahmed Adel Abdelgawad, Karim Abdel Aziz, Dina Aly El-Gabry

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Mood disorders are commonly associated with attention-deficit/hyperactivity disorder (ADHD), adding to the clinical complexity. Some symptoms associated with ADHD are often associated with an increase in emotional disorders and depression. Hence, the management of comorbid mood symptoms in the context of ADHD represents a particularly difficult clinical challenge. Few studies in literature, and probably none in the Arab world, have investigated the impact of individual common comorbid disorders on the efficacy of atomoxetine (a nonstimulant norepinephrine reuptake inhibitor) as a monotherapy for the treatment of these comorbid mood symptoms. Therefore, our aim was to investigate the effect of atomoxetine in a sample of drug-naive Egyptian children with ADHD, with and without comorbid mood disorders. Methods: A prospective, naturalistic, open-label study. Results: Atomoxetine is an effective treatment for the symptoms of ADHD in the presence of comorbid mood disorder, but with a slower rate of improvement than if applied in the absence of mood disorder; in addition, our study showed improvement regarding the depressive symptoms in the mood group after 1 month. Conclusions: The study highlighted that atomoxetine is an effective treatment for ADHD in the presence of comorbid mood disorder, and improves depressive symptoms in the mood group. It also predicts mild resistance to the effects of atomoxetine on ADHD with slower improvement than those with ADHD only.

Original languageEnglish
Pages (from-to)332-341
Number of pages10
JournalJournal of Child and Adolescent Psychopharmacology
Volume31
Issue number5
DOIs
Publication statusPublished - Jun 2021

Keywords

  • atomoxetine
  • attention-deficit/hyperactivity disorder
  • comorbidity
  • mood disorders

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Pharmacology (medical)

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