Assessment of deposition of inhaled aerosol in the respiratory tract of man using three-dimensional multimodality imaging and mathematical modeling

J. S. Fleming, A. H. Hashish, J. H. Conway, M. A. Nassim, S. T. Holgate, P. Halson, E. Moore, A. G. Bailey, T. B. Martonen

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Multimodality medical imaging enables measurement of the three- dimensional spatial distribution of a radiolabeled aerosol within the lung. Using a conceptual spatial morphological model these data may be transformed to provide information on deposition per airway generation. This methodology has been used to study the intrapulmonary deposition patterns of two formulations of a metered dose inhaler and two nebulizers in control subjects. The nebulizer study has also been simulated using a computer model of deposition. The comparison between derived experimental results and those from computer modeling shows areas of agreement, although there are also areas of discrepancy. The new methodology has considerable potential value in the fields of inhalation therapy and deposition modeling, although more detailed validation is still required.

Original languageEnglish
Pages (from-to)317-327
Number of pages11
JournalJournal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung
Volume9
Issue number3
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

Keywords

  • aerosols
  • deposition
  • radionuclide imaging

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)

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