Assessment of biological changes of continuous whole body exposure to static magnetic field and extremely low frequency electromagnetic fields in mice

A. H. Hashish, M. A. El-Missiry, H. I. Abdelkader, R. H. Abou-Saleh

Research output: Contribution to journalArticlepeer-review

103 Citations (Scopus)

Abstract

The question whether static magnetic fields (SMFs) and extremely low frequency electromagnetic fields (ELF-EMF) cause biological effects is of special interest. We investigated the effects of continuous whole body exposure to both fields for 30 days on some liver and blood parameters in mice. Two exposure systems were designed; the first produced a gradient SMF while the second generated uniform 50 Hz ELF-EMF. The results showed a gradual body weight loss when mice were exposed to either field. This is coupled with a significant decrease (P<0.05) in the levels of glucose, total protein and the activity of alkaline phosphatase in serum. A significant increase in lactate dehydrogenase activity was demonstrated in serum and liver paralleled with a significant elevation in hepatic γ-glutamyl transferase activity. The glutathione-S-transferase activity and lipid peroxidation level in the liver were significantly increased while a significant decrease in hepatic gluthathione content was recorded. A significant decrease in the counts of monocytes, platelets, peripheral lymphocytes as well as splenic total, T and B lymphocytes levels was observed for SMF and ELF-EMF exposed groups. The granulocytes percentage was significantly increased. The results indicate that there is a relation between the exposure to SMF or ELF-EMF and the oxidative stress through distressing redox balance leading to physiological disturbances.

Original languageEnglish
Pages (from-to)895-902
Number of pages8
JournalEcotoxicology and Environmental Safety
Volume71
Issue number3
DOIs
Publication statusPublished - Nov 2008

Keywords

  • Antioxidants
  • Electromagnetic fields
  • Enzymes
  • Liver

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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