Antioxidant, lipoxygenase and histone deacetylase inhibitory activities of acridocarbus orientalis from Al Ain and Oman

Taoufik Ksiksi, Alaaeldin A. Hamza

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Acridocarpus orientalis (AO) is a traditional medicinal plant used for treatment of inflammatory diseases that may have potential in cancer treatment. In the present study, the aqueous ethanolic crude extract of Acridocarpus aerial parts obtained from Al Ain and Oman were evaluated for their antioxidant capability, polyphenolic content, anti-lipoxygenase and anti-histone deacetylase (HDAC) properties. The total antioxidant capacity was estimated by the FRAP, DPPH, ABTS and β-carotene bleaching assays. Acridocarpus-Al Ain exhibited the highest polyphenol content (184.24 mg gallic acid/g) and the best antioxidant activity (1.1, 1.04, 1.14 mmol ascorbic acid equivalent/g in the FRAP, ABTS and DPPH assays, respectively). Additionally, the same extract showed significant anti-inflammatory properties via lipoxygenase (LOX) inhibitory activity (IC 50 = 50.58 μg/mL). Acridocarpus-Al Ain also showed the strongest histone deacetylase (HDACs) inhibitory activity (IC 50 = 93.28 μg/mL). The results reported here suggest that there was a significant influence of location and the plant may be considered a good source of compounds with antioxidant, anti-LOX and HDAC properties for therapeutic, nutraceutical and functional food applications.

Original languageEnglish
Pages (from-to)12521-12532
Number of pages12
JournalMolecules
Volume17
Issue number11
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Acridocarpus orientalis
  • Anti-histone deacetylase activity
  • Anti-lipoxygenase
  • Antioxidant
  • Total phenol

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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