Antimicrobial evaluation of new synthesized pyridine nucleosides under solvent-free conditions

Nora M. Rateb, Hany A. El-Deab, Ibrahim M. Abdou

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Two series of novel 3-cyano-2-(2,3,4,6-tetra-O-acetyl-β-D- glucopyranosyloxo) pyridines and 3-cyano-2-(2,3,5-tri-O-acetyl-β-D- ribofuranosyloxy)-4-trifluromethyl-6-phenyl pyridine were synthesized using efficient microwave methods. The targeted compounds were obtained in high yields by reacting 2-(1H)-pyridone or its salt with activated sugars using SiO 2 under solvent-free conditions. Ammonolysis of the resulted acetylated nucleosides produced 3-cyano-2-(β-D-glucopyranosyloxo)-pyridines and 3-cyano-2-(β-D-ribofuranosyloxy)-4-trifluoromethyl-6-phenyl pyridine. These new products were fully characterized using 1D and 2D NMR. These compounds were screened for their antibacterial activities against G+ and G- bacteria and some found to exhibit better antibacterial activities than the control drug.

Original languageEnglish
Pages (from-to)493-509
Number of pages17
JournalNucleosides, Nucleotides and Nucleic Acids
Volume32
Issue number9
DOIs
Publication statusPublished - Sep 2 2013

Keywords

  • 2(1H)-pyridone
  • antimicrobial
  • green synthesis
  • microwave
  • nucleosides
  • solvent-free conditions

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics

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