Anticancer activity of novel Schiff bases and azo dyes derived from 3-amino-4-hydroxy-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione

Abdeltawab Mohamed Saeed, Shaikha S. Alneyadi, Ibrahim M. Abdou

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

New Schiff bases and azo dyes derivatives have been synthesized via appropriate conventional methods using pyranoquinolinone as a starting material. The compounds obtained were characterized by spectral analysis and evaluated for anticancer activity in several human tumor cell lines: MCF-7 breast cancer, HepG2 liver cancer and HCT-116 colon carcinoma. 5-fluorouracil was used as a reference drug. The in vitro cytotoxicity screening results revealed that all tested compounds showed promising activity against MCF-7 cells. In particular, compounds 6a, 6b, and 7b showed excellent activity against the three human tumor cell lines. Structure-activity relationship studies indicated that the azo derivative with a trifluoromethoxy group (compound 7b) was the most potent candidate against the three human tumor cell lines (IC50, 1.82-8.06 μg/mL). Our findings highlight pyranoquinolinone analogues as a promising class of compounds for new anticancer therapies.

Original languageEnglish
Pages (from-to)192-205
Number of pages14
JournalHeterocyclic Communications
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 1 2020

Keywords

  • Schiff bases
  • anticancer
  • azo dyes
  • pyran
  • quinolinone

ASJC Scopus subject areas

  • Organic Chemistry

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