Anti-insulin receptor antibodies in the pathology and therapy of diabetes mellitus

Arshida Ashraf, Abdulrasheed Palakkott, Mohammed Akli Ayoub

Research output: Contribution to journalShort surveypeer-review

Abstract

Diabetes mellitus (DM) is recognized as the most common and the world’s fastest-growing chronic disease with severe complications leading to increased mortality. Many strategies exist for the management of DM and its control, including treatment with insulin and insulin analogs, oral hypoglycemic therapy such as insulin secretion stimulators and insulin sensitizers, and diet and physical training. Over the years, many types of drugs and molecules with an interesting pharmacological diversity have been developed and proposed for their anti-diabetic potential. Such molecules target diverse key receptors, enzymes, and regulatory/signaling proteins known to be directly or indirectly involved in the pathophysiology of DM. Among them, insulin receptor (IR) is undoubtedly the target of choice for its central role in insulin-mediated glucose homeostasis and its utilization by the major insulin-sensitive tissues such as skeletal muscles, adipose tissue, and the liver. In this review, we focus on the implication of antibodies targeting IR in the pathology of DM as well as the recent advances in the development of IR antibodies as promising anti-diabetic drugs. The challenge still entails development of more powerful, highly selective, and safer anti-diabetic drugs.

Original languageEnglish
Pages (from-to)198-206
Number of pages9
JournalCurrent Diabetes Reviews
Volume17
Issue number2
DOIs
Publication statusPublished - 2021

Keywords

  • Allosteric antibodies
  • Anti-diabetic drug
  • Autoantibodies
  • Diabetes
  • Insulin receptor
  • Therapeutic antibodies

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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