Anti-hyperlipidemic effect of methanol bark extract of Terminalia chebula in male albino Wistar rats

Murali Mohan Reddy, Jackson Dhas Devavaram, Jebasingh Dhas, Ernest Adeghate, Bright Starling Emerald

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Context: Hyperlipidemia is known to be a major risk factor for the development of cardiovascular diseases (CVDs) which include atherosclerosis, coronary heart disease, and stroke. Although there are a large number of anti-hyperlipidemic drugs available, unfortunately, they all have side effects. Objective: Terminalia chebula Retz. (Combretaceae) is a plant used to treat cardiac disorders in the traditional Ayurveda medicine in India. The objective of this study was to assess the anti-hyperlipidemic properties of a methanol (MeOH) bark extract of T. chebula. Materials and methods: Acute toxicity studies were performed according to the Organisation for Economic Cooperation and Development (OECD) guideline no. 423 using various doses (5, 50, 300, and 2000 mg/kg) of T. chebula bark. Anti-hyperlipidemic effect of MeOH bark extract of T. chebula at doses of 200, 400, and 600 mg/kg and fasting glucose levels after treatment with MeOH bark extract of T. chebula at doses of 200, 400, and 600 mg/kg were analyzed using commercially available kits. Results: Acute toxicity studies did not show any morbidity and mortality at various doses. The MeOH extract of T. chebula bark at doses of 200, 400, and 600 mg/kg significantly lowered serum cholesterol and triglyceride levels. Moreover, the extract of T. chebula and the positive control atorvastatin-treated groups of animals showed a significant increase in the serum high-density lipoprotein (HDL) cholesterol levels in diet-induced hypercholesterolemic animals. Conclusion: The overall results confirm that the bark extract of T. chebula possesses significant anti-hyperlipidemic activity.

Original languageEnglish
Pages (from-to)1133-1140
Number of pages8
JournalPharmaceutical Biology
Volume53
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

Keywords

  • Acute toxicity study
  • Anti-hyperlipidemic property
  • MeOH bark extract
  • Statins

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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