Andrographis paniculata extract protect against isoproterenol-induced myocardial injury by mitigating cardiac dysfunction and oxidative injury in rats

Shreesh Ojha, Saurabh Bharti, Mahaveer Golechha, Ashok K. Sharma, Neha Rani, Santosh Kumari, Dharamvir Singh Arya

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Present study evaluated the cardioprotective effect of Andrographis paniculata (100, 200 or 400 mg/kg) against isoproterenol (85 mg/kg, b.w.)-induced cardiotoxicity referred as myocardial infarction in rats. Isoproterenol significantly (p < 0.05) decreased mean arterial pressure, heart rate, contractility and relaxation and increased left ventricular end diastolic pressure. Isoproterenol also significantly (p < 0.05) decreased antioxidants, superoxide dismutase, catalase, glutathione peroxidase, glutathione and increased leakage of cardiac injury markers; creatine phosphokinase-MB isoenzyme, lactate dehydrogenase concomitant to increased lipid peroxidation and histopathological perturbations. However, pretreatment with A. paniculata favorably restored hemodynamic parameters and left ventricular function and significantly (p < 0.05) prevented the depletion of endogenous antioxidants and myocyte marker enzymes as well as inhibited lipid peroxidation. Significant (p < 0.05) reversal of almost all the hemodynamic, biochemical and histopathological parameters by A. paniculata pretreatment in isoproterenol-induced cardiotoxicity depicted the cardioprotective effect of A. paniculata. Results showed that A. paniculata protected heart against cardiotoxic effects of isoproterenol by boosting endogenous antioxidant network, restoring ventricular function and maintaining structural integrity of heart.

Original languageEnglish
Pages (from-to)269-278
Number of pages10
JournalActa Poloniae Pharmaceutica - Drug Research
Volume69
Issue number2
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Andrographis paniculata
  • Cardiotoxicity
  • Infarction
  • Isoproterenol
  • Myocardial necrosis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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