Aloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokines

Lalit Birari, Shivani Wagh, Kalpesh R. Patil, Umesh B. Mahajan, Banappa Unger, Sateesh Belemkar, Sameer N. Goyal, Shreesh Ojha, Chandragouda R. Patil

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Purpose: Aloin, an anthraquinone present in the aloe species, possesses antiangiogenic, chemopreventive and antioxidant properties. It exerts cytotoxicity against breast cancer and ovarian cancer cell lines. These properties of aloin project it as a chemopreventive adjuvant to anticancer chemotherapy. Methods: We evaluated the effect of concurrent oral administration of aloin against doxorubicin (DOX)-induced cardiotoxicity in rats. The protective effects of aloin against DOX-induced toxicity were evident as a statistically significant inhibition of a rise in the biochemical markers of myocardial damage including lactate dehydrogenase (LDH), creatinine kinase-myocardial band (CK-MB), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Results: Aloin dose dependently inhibited the DOX-induced changes in ECG like increased ST-height and prolonged QT interval. It protected heart against the lipid peroxidation and restored the levels of antioxidative defenses: reduced glutathione, catalase and superoxide dismutase. Aloin prominently reduced the levels of proinflammatory cytokines- TNF-α, IL-1β and IL-6. Notably, the significant protective effects of aloin were evident even at the strikingly lower doses of 1 and 5 mg/kg per day. Conclusion: Our results highlight the necessity to further investigate the chemopreventive effects of aloin against other chemotherapeutic agents.

Original languageEnglish
Pages (from-to)419-426
Number of pages8
JournalCancer Chemotherapy and Pharmacology
Volume86
Issue number3
DOIs
Publication statusPublished - Sep 1 2020

Keywords

  • Aloin
  • Cytokines
  • Doxorubicin
  • Oxidative stress

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

Fingerprint

Dive into the research topics of 'Aloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokines'. Together they form a unique fingerprint.

Cite this