Adaptation and Validation of the Mini-Addenbrooke's Cognitive Examination in Dementia in Arabic Speakers in Egypt

Tarik Qassem, Mohamed S. Khater, Tamer Emara, Doha Rasheedy, Heba M. Tawfik, Ahmed S. Mohammedin, Mohammad F. Tolba, Heba G. Saber, DIna Aly El-Gabry, Karim Abdel Aziz

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: The mini-Addenbrooke's Cognitive Examination (m-ACE) is a brief cognitive battery that assesses 5 subdomains of cognition (attention, memory, verbal fluency, visuospatial abilities, and memory recall). It is scored out of 30 and can be administered in under 5 min providing a quick screening tool for assessment of cognition. Objectives: We aimed to adapt the m-ACE in Arabic speakers in Egypt and to validate it in dementia patients to provide cutoff scores. Methods: We included 37 patients with dementia (Alzheimer's disease [n = 25], vascular dementia [n = 8], and dementia with Lewy body [n = 4]) and 43 controls. Results: There was a statistically significant difference (p < 0.001) on the total m-ACE score between dementia patients (mean 10.54 and standard deviation [SD] 5.83) and controls (mean 24.02 and SD 2.75). There was also a statistically significant difference between dementia patients and controls on all sub-score domains of the m-ACE (p < 0.05). Performance on the m-ACE significantly correlated with both the Mini-Mental State Examination (MMSE) and the Addenbrooke's Cognitive Examination-III (ACE-III). Using a receiver operator characteristic curve, the optimal cutoff score for dementia on the m-ACE total score was found to be 18 (92% sensitivity, 95% specificity, and 94% accuracy). Conclusions: We adapted the m-ACE in Arabic speakers in Egypt and provided objective validation of it as a screening tool for dementia, with high sensitivity, specificity, and accuracy.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalDementia and Geriatric Cognitive Disorders
Volume49
Issue number6
DOIs
Publication statusPublished - Apr 2021

Keywords

  • Adaptation
  • Arabic
  • Dementia
  • Egypt
  • Mini-Addenbrookes Cognitive Examination
  • Validation

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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