Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines

Louise A. Rollins-Smith, Cynthia Carey, J. Michael Conlon, Laura K. Reinert, Jennifer K. Doersam, Tomas Bergman, Jerzy Silberring, Hilkka Lankinen, David Wade

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

Temporin A and structurally related peptides produced in amphibian dermal granular glands and in wasp venom were tested for growth inhibition of Batrachochytrium dendrobatidis, a pathogen associated with global amphibian declines. Two natural amphibian temporins, a wasp temporin, and six synthetic analogs effectively inhibited growth. Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an α-helical structure is important for their effectiveness against this pathogen.

Original languageEnglish
Pages (from-to)1157-1160
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number3
DOIs
Publication statusPublished - Mar 3 2003
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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