Activation of somatostatin receptor subtype 2 inhibits insulin secretion in the isolated perfused human pancreas.

F. Charles Brunicardi, Azmi Atiya, Stefan Moldovan, Timothy C. Lee, Shawn P. Fagan, Robert M. Kleinman, Thomas E. Adrian, David H. Coy, John H. Walsh, William E. Fisher

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

OBJECTIVES: Five distinct somatostatin receptors (SSTRs) have been cloned, characterized, and designated SSTRs 1-5. The role of these receptors in B-cell signaling has not been well characterized. METHODS: In the current study, the isolated perfused human pancreas model was used to determine the specific effect of 4 different somatostatin receptor agonists on insulin secretion. CONCLUSION: We demonstrated that the SSTR 2 agonist and octreotide significantly suppressed insulin secretion. Furthermore, even during the immunoneutralization of endogenous intrapancreatic somatostatin, the SSTR 2 agonist was able to reverse the effect of somatostatin immunoneutralization by suppressing insulin secretion. These results demonstrate that activation of SSTR 2 suppresses insulin secretion in the isolated perfused human pancreas.

Original languageEnglish
Pages (from-to)e84-89
JournalPancreas
Volume27
Issue number4
DOIs
Publication statusPublished - Nov 2003
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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