Acetazolamide stimulation test in patients with unilateral internal carotid artery obstructions using transcranial Doppler and 99mTc-HM-PAO- Spect

K. Rosenkranz, J. Hierholzer, R. Langer, W. Hepp, J. Palenker, R. Felix

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Fifteen patients with symptoms of cerebral ischaemia and angiographically confirmed unilateral stenoses or occlusions of the extracranial internal carotid artery (ICA) and 20 controls were studied by a 2 MHz transcranial Doppler (TCD) at rest and after stimulation with 1 g acetazolamide i.v., a cerebral vasodilator. In addition,-the patients underwent 99mTc-HM-PAO- Spect measurement of regional cerebral blood flow (rCBF) at rest and after stimulation with 1 g acetazolamide. In 10 patients with ICA stenoses >80% or occlusions, time-mean velocity (V(mean)) increase and pulsatility index (PI) decrease in the postobstructive middle cerebral artery (MCA) as well as the increase of the ipsilateral rCBF were reduced in comparison with the contralateral side. The remaining 5 patients showed a normal V(mean) increase and PI decrease in TCD.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalNeurological Research
Volume14
Issue number2 SUPPL.
DOIs
Publication statusPublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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