A new locus for non-syndromal, autosomal recessive, sensorineural hearing loss (DFNB16) maps to human chromosome 15q21-q22

D. A. Campbell, D. P. McHale, K. A. Brown, L. M. Moynihan, M. Houseman, G. Karbani, G. Parry, A. H. Janjua, V. Newton, L. Al-Gazali, A. F. Markham, N. J. Lench, R. F. Mueller

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Non-syndromal, recessive deafness (NSRD) is the most common form of inherited deafness or hearing impairment in humans. NSRD is genetically heterogeneous and it has been estimated that as many as 35 different loci may be involved. We report the mapping of a novel locus for autosomal recessive, non-syndromal deafness (DFNB16) in three consanguineous families originating from Pakistan and the Middle East. Using multipoint analysis (HOMOZ/MAPMAKER) a maximum combined lod score of 6.5 was obtained for the interval D15S1039-D15S123. Recombination events and haplotype analysis define a 12-14 cM. critical region between the markers D15S1039 and D15S155 on chromosome 15q15-q21.

Original languageEnglish
Pages (from-to)1015-1017
Number of pages3
JournalJournal of medical genetics
Volume34
Issue number12
DOIs
Publication statusPublished - 1997

Keywords

  • Autosomal recessive
  • Autozygosity mapping
  • Sensorineural deafness

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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