A narrative role of vitamin d and its receptor: With current evidence on the gastric tissues

Shaima Sirajudeen, Iltaf Shah, Asma Al Menhali

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)

Abstract

Vitamin D is a major steroid hormone that is gaining attention as a therapeutic molecule. Due to the general awareness of its importance for the overall well-being, vitamin D deficiency (VDD) is now recognized as a major health issue. The main reason for VDD is minimal exposure to sunlight. The vitamin D receptor (VDR) is a member of the steroid hormone receptors that induces a cascade of cell signaling to maintain healthy Ca2+ levels that serve to regulate several biological functions. However, the roles of vitamin D and its metabolism in maintaining gastric homeostasis have not yet been completely elucidated. Currently, there is a need to increase the vitamin D status in individuals worldwide as it has been shown to improve musculoskeletal health and reduce the risk of chronic illnesses, including some cancers, autoimmune and infectious diseases, type 2 diabetes mellitus, neurocognitive disorders, and general mortality. The role of vitamin D in gastric homeostasis is crucial and unexplored. This review attempts to elucidate the central role of vitamin D in preserving and maintaining the overall health and homeostasis of the stomach tissue.

Original languageEnglish
Article number3832
JournalInternational journal of molecular sciences
Volume20
Issue number15
DOIs
Publication statusPublished - Aug 1 2019

Keywords

  • 1,25-MARRS
  • 1α,25(OH)D
  • Cytochrome P450
  • Stomach
  • Vitamin D deficiency
  • Vitamin D epimers

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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