A comparative map of the porcine and human genomes demonstrates ZOO-FISH and gene mapping-based chromosomal homologies

L. Frönicke, B. P. Chowdhary, H. Scherthan, I. Gustavsson

Research output: Contribution to journalArticlepeer-review

148 Citations (Scopus)

Abstract

ZOO-FISH with chromosome-specific DNA libraries (CSLs) from individual flow-sorted human chromosomes was applied on porcine metaphase chromosomes to establish segment homology between the pig and human karyotypes. Forty-seven porcine chromosomal segments corresponding to all human chromosomes except the Y were delineated, resulting in a nearly complete coverage of the porcine karyotype. The syntenic segments detected were further confirmed by the gene mapping information available in the two species. A map demarcating physical boundaries of human homologies on individual pig chromosomes is complemented with a detail survey of the physical and genetic linkage mapping data in the two species. The resultant map, thus, provides a comprehensive and updated comparative status of the human and porcine genomes.

Original languageEnglish
Pages (from-to)285-290
Number of pages6
JournalMammalian Genome
Volume7
Issue number4
DOIs
Publication statusPublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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