A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models

Andrea Mari, L. Stojanovska, J. Proietto, A. W. Thorburn

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

This study presents a circulatory model of glucose kinetics for application to non-steady-state conditions, examines its ability to predict glucose appearance rates from a simulated oral glucose load, and compares its performance with compartmental models. A glucose tracer bolus was injected intravenously in rats to determine parameters of the circulatory and two-compartment models. A simulated oral glucose tolerance test was performed in another group of rats by infusing intravenously labeled glucose at variable rates. A primed continuous intravenous infusion of a second tracer was given to determine glucose clearance. The circulatory model gave the best estimate of glucose appearance, closely followed by the two-compartment model and a modified Steele one-compartment model with a larger total glucose volume. The standard one-compartment model provided the worst estimate. The average relative errors on the rate of glucose appearance were: circulatory, 10%; two-compartment, 13%; modified one-compartment, 11%; standard one-compartment, 16%. Recovery of the infused glucose dose was 93±2, 94±2, 92±2 and 85±2%, respectively. These results show that the circulatory model is an appropriate model for assessing glucose turnover during an oral glucose load.

Original languageEnglish
Pages (from-to)269-281
Number of pages13
JournalComputer Methods and Programs in Biomedicine
Volume71
Issue number3
DOIs
Publication statusPublished - Jul 2003
Externally publishedYes

Keywords

  • Glucose kinetics
  • Mathematical models
  • Oral glucose test
  • Tracer method

ASJC Scopus subject areas

  • Software
  • Computer Science Applications
  • Health Informatics

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